Fig 3A shows the loading scores of all variables predicting CFR and Fig 3B shows the distribution score of subjects along the principal component describing CFR. As can be seen by the amplitude and direction of the corresponding loadings, the use of statins, hypertension, HOMA-IR, systolic blood pressure (SBP), use of beta blockers, use of aspirin, insulin, hyperlipidemia, previously known CAD, previous myocardial infarction, age, HbA1c, glucose, osteopontin and eosinophil counts were all negative predictors of CFR. The gene discussed is SPP1; the disease is myocardial infarction.