ITK and Hepatosplenomegaly: The ITK deficiency is associated with naive CD4+ T-cell lymphopenia, modest change in the number of CD4+ T-cells, impaired positive and negative selection of thymocytes due to reduced TCR signal levels, recurrent infections (for example, herpes virus infections), autoimmune cytopenias, lymphoproliferation, lymphadenopathy and hepatosplenomegaly.