Xanthine oxidase inhibitors (e.g., allopurinol, febuxostat, topiroxostat) and uricosuric agents (e.g., probenecid, benzbromarone) are famous medicines for gout and hyperuricemia treatments, but some angiotensin receptor blockers (e.g., losartan, irbesartan), sodium-glucose co-transporter 2 (SGLT2) inhibitors and anti-dyslipidemia drugs (e.g., fenofibrate) facilitate uric acid excretion in the kidney. The gene discussed is XDH; the disease is metabolic syndrome.