SLC22A12 and hypouricemia, renal: Renal hypouricemia (RHUC) is mainly caused by urate transporter mutations such as SLC22A12 (URAT1): RHUC type 1 and SLC2A9 (GLUT9/URATv1): RHUC type 2,[11–15] because urate transporter works to reabsorb uric acid mainly from proximal tubular in kidney.