The amount of collagen and the level of maturation of the collagen fibers in the scar can be modulated by both the expression of adenylyl cyclase 6 (AC6) or the use of forskolin [18], suggesting that targeting these parameters may affect the final scar composition, which in turn will improve the mechanics of the pump and overall heart function post-MI [4]. The gene discussed is ADCY6; the disease is myocardial infarction.