We document a sharp increase in the inflammatory response in terms of Ifng, Tnfa, Il6, Il1b, Il1r1, Cxcl9 and Cxcl10 expression already on day 6 post-infection in WT mice, and of Cd8a on day 7, which were essentially absent in ST2-/- mice on day 5 to 7 after PbA-infection (Fig 5A–5H). Here, IL1R1 is linked to infection.