Previous studies demonstrated that corticosteroids like Dex phosphate contributed to an anti-inflammatory effect through inhibiting the nuclear factor-kappa B (NF-κB) signal pathway.[5, 6] However, whether corticosteroids eye drops are proper for infectious keratitis cure remains a controversial topic.[7] Lu et al. proved that dexamethone could inhibit IL-1-induced collagen degradation and decrease stroma scarring.[3] On the other hand, corticosteroids may have pro-apoptotic effect on corneal epithelial cells and keratocytes,[8] which may worsen corneal stroma ulcer during keratitis. This evidence concerns the gene NFKB1 and keratitis.