Interestingly, other sirtuins, and especially Sirt1, have been shown to play a role in genetically determined and age-related retinal degeneration in rodent models [37–39] and activation of Sirt1 by oral supplementation of a SIRT1 activator, resveratrol, was shown to attenuate light-induced retinal injury and age-related retinal dysfunction in mice and rats [39, 40]. This evidence concerns the gene SIRT1 and injury.