ALPL and Klebsiella pneumonia: Human TNAP significantly dephosphorylated the double-stranded RNA mimic Poly I:C (p = 0.002, TLR3A) as well as LPS from Klebsiella pneumonia (p = 0.0006) and Salmonella minnesota Re595 (p = 0.009, TLR4As; Fig 1).