While the molecular biology of sepsis is complex [33], these ALP mediated improvements in renal function could reflect culture-negative endotoxemia [34], potential effects of ALP in detoxifying microbial products other than LPS, and/or alteration by ALP of host responses via production of anti-inflammatory adenosine by dephosphorylating extracellular adenosine monophosphate (AMP) [23]. Here, ALPP is linked to Sepsis.