We performed univariate and stepwise multiple linear regression analysis with factors which were related to quality of life including sex, age, work status, co-morbidity (DM and HTN), renal function, serum 25(OH)D level, hemoglobin, serum albumin, hsCRP, lipid profile (to reflect nutritional status), markers for CKD-MBD, education level, economic status and some other variables. The gene discussed is ALB; the disease is hypertensive disorder.