To test this, we generated a series of Myc-tagged prostate cancer-associated mutants of SPOP, including Y87C, Y87N, F102C, S119N, F125V, K129E, W131G, W131C, F133L, F133V and K134N, and examined their interactions with INF2 by co-IP assays. Here, SPOP is linked to prostate cancer.