Interestingly, this TGF-β activity also correlated with expression of an experimentally validated 6-gene “metagene” (VAV2, CORO1A, EPB41L1, CCT4, FRAP1, GJB3) reflecting integrin β1 activity, further supporting a link between integrin activity and TGF-β activity in human melanoma (Fig 2A) [36]. This evidence concerns the gene MTOR and melanoma.