TP53 and ovarian cancer: However, MK 8776 failed to sensitise p53 mutant TNBC cells to cisplatin treatment [76] and, although V158411 did potentiate the cytotoxic effects of cisplatin and carboplatin in a number of TNBC and ovarian cancer cell lines in a p53 dependent manner [78], the effect was significantly less than in combination with gemcitabine.