Among the former, it should be mentioned the action on insulin receptor substrate-1 (IRS-1), and platelet-derived growth factor receptor (PDGFR) signaling that drives tumor cell proliferation, promotion of angiogenesis through the production of cytokines and angiogenic factors, and the regulation of both the innate and the adaptive immune responses through interactions with the other immune cells [6]. Here, IRS1 is linked to neoplasm.