BRCA1 and Familial prostate cancer: We used the estimated OR for the breast cancer overall PRS and the prostate cancer PRS from the combined analysis of BRCA1/2 samples to calculate male breast and prostate cancer risks at the 5th, 10th, 50th, 90th, and 95th percentiles of PRS distributions (Figs 1, 2, and 3 and Data Supplement).