BRCA1 and Familial prostate cancer: Germline mutations in BRCA1 and, predominantly, BRCA2 are associated with increased risks in men of developing breast and prostate cancers.1,2BRCA1/2 mutations account for approximately 10% of male breast cancer and 2% of prostate cancer cases.3-5 Breast cancer in men is rare and accounts for less than 1% of all male tumors.