BRCA2 and breast cancer: For BRCA2 carriers, the risk of breast cancer by age 80 years is 5% for men at the 5th percentile of the PRS and 14% for men at the 95th percentile; the risk of prostate cancer by age 80 years is 19% for men at the 5th percentile of the PRS and 61% for men at the 95th percentile.