Studies by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) have shown that common SNPs modify the risk of breast and ovarian cancers for female BRCA1 and BRCA2 mutation carriers20-22; however, no study to date has investigated the associations of common SNPs with breast or prostate cancer risk for men with BRCA1/2 mutations and their implications for cancer risk prediction. This evidence concerns the gene BRCA2 and cancer.