One of the multiple risk loci in this genomic region lies within the CLPTM1L gene and has been termed Region 2 (ref. 18), originally reported to be associated with risk of pancreatic, lung, bladder cancer, and melanoma, marked by either rs401681 or rs402710 (refs 1, 4, 5, 11, 28). This evidence concerns the gene CLPTM1L and melanoma.