To summarize, our results open up a therapeutic window were IGF-1R inhibition could be given to patients with metastatic PCa during a short period of time in order to boost acute anti-proliferative and pro-apoptotic effects of ADT or other therapies given for CRPCa, although with the possibility that response may differ depending on tumor cell microenvironment and thus metastatic site. Here, IGF1R is linked to posterior cortical atrophy.