IGF1R and neoplasm: To summarize, our results open up a therapeutic window were IGF-1R inhibition could be given to patients with metastatic PCa during a short period of time in order to boost acute anti-proliferative and pro-apoptotic effects of ADT or other therapies given for CRPCa, although with the possibility that response may differ depending on tumor cell microenvironment and thus metastatic site.