This was also associated with a shift from Th2 and Th17 to Th1 in the form of cytokine and switching of antibody class, which appears to be mainly due to the selective depletion of induced T regulatory cells (CD4+CD25+FoxP3+ CD39+FR4+GITR+CD127−) in blood, spleen, lymph node, and the tumor (258). Here, CD4 is linked to neoplasm.