Metabolic reprogramming of cancer cells is a complex interplay of various signaling pathways [like phosphoinositide-3-kinase (PI3K), mammalian target of rapamycin (mTOR), Akt, PTEN, AMP-activated protein kinase (AMPK), and Notch] regulated by a plethora of transcription factors including hypoxia-inducible factor (HIF) 1α, c-Myc, and p53 (12, 34, 35). The gene discussed is MTOR; the disease is cancer.