When the blood-brain barrier is damaged by stroke or ischemia, due to changes in the structural proteins (collagen type IV, fibronectin, and laminin), the ability to selectively differentiate the products of cerebrovascular system is impaired and vasogenic edema and changing the properties of neuronal microenvironment can ensue (Del Zoppo, 2010; Del Zoppo & Mabuchi, 2003). Here, FN1 is linked to ischemia.