By contrast, the A/A genotype might correlate with higher CTLA-4 expression not only on Teff and Treg cells but also on tumor cells (29) thus facilitating tumor cellular lysis through an IPI-dependent cell-mediated cytotoxicity by Fcγ receptor expressing immune cells, such as monocytes for Treg cells (30) or NK and Tγδ cells for tumor cells (29). The gene discussed is CTLA4; the disease is neoplasm.