Nevertheless, IPI may still have a role as (i) a subsequent therapy in metastatic patients after progressive disease with anti-PD-1 and, if BRAF-mutant, BRAF/MEK inhibitors; (ii) an adjuvant therapy for high-risk stage III melanoma; and (iii) a combination therapy with anti-PD-1 drugs. Here, MAP2K7 is linked to melanoma.