ESR1 and Obesity: Lastly, obesity networks (e.g., transcripts including Retn, Lpl, Lep, Esr1, Lipc, Hsd11b1, Gpt, Lipe, Vldlr, and Il6, among others, fold change −1.042, P < 0.05) were also decreased by 4% (1.04-fold).