Taken together, the translocation of HMGB1 in neurons, decreased HMGB1 levels in the brain and increased HMGB1 level in plasma in mice with pilocarpine-induced epilepsy support the notion that HMGB1 was translocated and released from neuronal nuclei into the surrounding areas, including the blood stream. The gene discussed is HMGB1; the disease is epilepsy.