Moreover, EL was recognized as an important provider of lipoprotein-derived fatty acids to cardiac tissue of mice with pressure overload-induced heart failure (HF), a pathophysiological condition accompanied by an increased energy demand and a decreased cardiac lipoprotein lipase (LPL) expression; EL deficient mice presented more severe HF than wild type mice due to decreased cardiac uptake of fatty acids18. Here, LPL is linked to hydrops fetalis.