Further functional studies also revealed that TMEM230 not only was involved in retromer trafficking and Rab8a-mediated exophagy and classical secretion but also shared a converging pathway with leucine-rich repeat kinase 2 (LRRK2), which provided several lines of evidence for the association between TMEM230 and PD pathogenesis12. The gene discussed is TMEM230; the disease is Parkinson disease.