Accordingly, a substantial decrease in cardiac hypertrophy was found, with a significant reduction in left ventricular weight:tibia length ratio (Figure 7B, online-only Data Supplement Table V) and in cardiac fibrosis, remodeling, and inflammation, shown by a significant reduction in collagen type 3, atrial natriuretic peptide, and NOX-2 mRNA expression (online-only Data Supplement Table VI). The gene discussed is NPPA; the disease is cardiac hypertrophy.