CALCA and heart failure: Myocyte apoptosis is well documented in heart failure and CGRP regulates cell survival signaling and antiapoptotic pathway via CLR/RAMP1 in cardiomyocytes.38,48 Although the αAnalogue reduces nuclear factor kappa B cells and apoptotic marker p53 expression in our acute AngII model, here, the αAnalogue reduced apoptosis, as revealed in terminal deoxynucleotidyl transferase dUTP nick-end labeling staining with increased p38 mitogen-activated protein kinase phosphorylation in the hypertrophic heart.