Klotho has nephroprotective effects, and AngII-induced downregulation of klotho aggravates renal damage in hypertension.24 This downregulation was rescued by the αAnalogue, and our results further confirm the link between klotho and CGRP.29 The upregulation of klotho associated with the use of αAnalogue may translate into enhanced renal protection in hypertension. The gene discussed is CALCA; the disease is hypertensive disorder.