AKT1 and ischemia reperfusion injury: CGRP regulates oxidative stress by the PI3K/Akt and mitogen-activated protein kinase signaling pathways,38 and deletion of the CGRP gene exacerbates cardiac oxidative stress in ischemia-reperfusion injury.39 The αAnalogue protects against AngII-induced changes in the endogenous antioxidant defense responses and nitrosative stress.