CALCA and renal fibrosis: Hypertension is associated with renal fibrosis and inflammation that were reduced by the αAnalogue, complementing knowledge that CGRP promotes renal protection in hypertension independently of its vasodilator action.33,45 The αAnalogue preserved renal function by reducing mesangial matrix expansion, plasma and kidney creatinine levels, and expression of cystatin C and neutrophil gelatinase-associated lipocalin, the early biomarker of acute kidney injury.