A link between CGRP and HO-1 is known.40 Activation of HO-1 and NADPH dehydrogenase quinone-1 can counteract hypertension, potentially through generating the vasodilator carbon monoxide41,42 and improved endothelial nitric oxide synthase coupling.43 Our data build on earlier findings in cardiomyocytes, smooth muscle cells, and α-CGRP KO mice, implying that the αAnalogue acts directly via its receptors on the heart and reduces stress-activated kinases induced by oxidative stress,44 adverse tissue remodeling to preserve cardiac function. The gene discussed is CALCA; the disease is Hypertension.