CALCA and hypertensive disorder: Although α-CGRP–specific KO mice have normal basal cardiovascular hemodynamics, they exhibit an enhanced hypertensive phenotype in AngII-induced hypertension.7 Indeed, acute injection of the native CGRP peptide was beneficial in hypertensive rats26 but effects were short lasting (<10 minutes) because of its short half-life.27 In contrast, CGRP infusion for 6 days had beneficial effects in hypertensive rats.3 To build on this and elucidate the mechanisms, we show that the αAnalogue protects against AngII-induced increase in blood pressure for 2 weeks.