CGRP has positive chronotropic effects,31 and α-CGRP KO mice exhibit exacerbated cardiac dysfunction in pressure overload–induced hypertrophy32 and deoxycorticosterone acetate salt–induced hypertension.33,34 Here, the αAnalogue had no effect on in vivo heart function, as observed by radiotelemetry or echocardiography in sham mice, but protected against cardiac hypertrophy in AngII-induced hypertension. The gene discussed is CALCA; the disease is cardiac hypertrophy.