RAMP1 determines the CGRP receptor phenotype when associated with CLR, and CGRP receptors are upregulated in cardiovascular disease models.1 We observed a significant increase in CGRP receptor RAMP1 protein expression in the aorta, mesentery, and heart of vehicle-treated AngII-infused mice but not the αAnalogue (Figure 6). This evidence concerns the gene DCLK3 and cardiovascular disorder.