Growth factor receptors, such as epidermal growth factor receptor 1 (EGFR), human epidermal growth factor receptor 2 (HER2), and insulin-like growth factor 1 receptor (IGF1R), are key regulatory nodes of the GFRN and are often aberrantly activated across breast cancer subtypes [6, 12, 13]. The gene discussed is ERBB2; the disease is breast carcinoma.