Kcne2 is ubiquitously expressed, in the heart but also pancreatic islet cells, gastric parietal cells, the thyroid and other epithelia, and its deletion also causes diabetes, atherosclerosis and fatty liver in mice [16, 38–42]; Kcne2 polymorphisms also influence risk if coronary artery disease in human populations [43, 44]. This evidence concerns the gene KCNE2 and diabetes mellitus.