In addition, Ohshima et al. reported that galectin-3 and its binding protein is overexpressed in the RA synovial membrane, particularly at the invading pannus front, and that galectin-3 in the serum and synovial fluid is increased in patients with long-standing RA compared with osteoarthritis and healthy controls [14]. This evidence concerns the gene LGALS3 and osteoarthritis.