S100A11 and rheumatoid arthritis: In RA patients, synovial fluid S100A11 levels were significantly associated with disease activity as represented by the DAS28 (r = 0.350, p = 0.027), CRP (r = 0.463, p = 0.003) and synovial fluid leukocyte count (r = 0.677, p < 0.001) (Fig. 3c–e).