More p-TrkB was also observed in cultured brain metastasis cells (BBM1 and BBM2) as compared to TN brain metastasis (MDA-MB-231Br ((231 Br)) and Her2+ primary breast cancer cell lines (SkBr3) (Fig. 1c and Additional file 2: Figure S1b). Here, NTRK2 is linked to breast carcinoma.