By constructing gene regulatory networks in 1647 postmortem brain tissues from late-onset Alzheimer’s disease (LOAD) patients and normal subjects, an immune and microglia-related module dominated by genes participating in pathogen phagocytosis was identified, with TYROBP as a key causal regulator upregulated in LOAD [70]. Here, TYROBP is linked to early-onset autosomal dominant Alzheimer disease.