ABCG2 and Alzheimer disease: However, six members from the same family were included in Alzgset (ABCA1, ABCA2, ABCA7, ABCC2, ABCG1, and ABCG2), and there was experimental evidence for their involvement in AD; for example, the expression reduction or loss of function of ABCA7 could alter Alzheimer amyloid processing [39].