Consistent with this view, more and more genes—e.g., apolipoprotein E (APOE), glycogen synthase kinase 3 beta (GSK3B), dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), and Tau—have been found to be potentially associated with AD [1, 13]. Here, APOE is linked to Alzheimer disease.