In the brain, pathway analysis of uniquely modulated genes identified pathways such as, glioma, neuropathic pain, acute phase, JAK/Stat, Toll-like Receptor (TLR), chemokine and T-cell receptor (TCR) signaling pathways to be similarly modulated during infection with either of the VEEV strains (Fig. 5). This evidence concerns the gene SOAT1 and glioma.