V3000 infection uniquely modulated several inflammatory signaling pathways such as IL-2, IL-4, IL-8, IL-9, IL-12 and IL-17A along with the unfolded protein response, gap junction signaling, crosstalk between DCs and NKCs, interferon and JAK/Stat signaling pathways (Fig. 4a). The gene discussed is CXCL8; the disease is infection.