Likewise, carriers of the DGKB/TMEM195 rs2191349 G minor-allele had an association with increased risk of CRC in obese women (BMI ≥ 30, waist >88 cm, and w/h > 0.85) (Table 5 and Additional file 4: Table S4.2). This evidence concerns the gene DGKB and colorectal carcinoma.