Since NSCLC cell lines expressed multiple FGFs and FGFRs, we used phosphorylation of the FGFR docking protein fibroblast growth factor receptor substrate 2 (FRS2) [24] as a readout for signaling from the FGFR pathway in the presence of AZD4547 and fulvestrant (Figure 5). This evidence concerns the gene FRS2 and non-small cell lung carcinoma.