In the case of FGF2, the proportion of fields with a high score in adenomas was reduced from 9/12 (75%) with placebo treatment to 2/13 (15.4%) for fulvestrant alone, 0/10 (0%) for anastrozole alone, and 1/12 (8.3%) with combination treatment, while the proportion of low grade scores increased with treatments (Figure 1E, P < 0.003 for all treatment groups). This evidence concerns the gene FGF2 and adenoma.