As shown in Figure 8, the qRT-PCR findings validated the observed increased levels of FGFR1 mRNA (P = 0.0004) and down-regulation of mRNA for the decoy receptor FGFRL1/FGFR5 (P = 0.0116) in the ERβ high NSCLC tumors compared to ERβ low tumors, confirming the microarray findings of a relationship between the FGFR pathway and ER status in NSCLC. The gene discussed is ESR2; the disease is non-small cell lung carcinoma.