AP1S2 and metastatic melanoma: Clinically, the oncosuppressive role played by miR-204 in melanoma cells through its ability to impair cell motility is further supported by the GSE 19234 dataset [41], where metastatic melanoma patients with high TRPM3/AP1S2 ratio show a trend toward higher overall survival compared to those with low TRPM3/AP1S2 ratio (Figure 6f and Supplementary Figure 21).