Furthermore, we found that a high TRPM3/AP1S2 ratio correlates with higher overall survival in metastatic melanoma samples (Figure 6f), a trend that reaches statistical significance when we consider the ratio between TRPM3/AP1S2 and TRPM1/EDEM1, or the TRPM3/TRPM1 ratio, which equals to say when we consider the subset of patients with high TRPM3/miR-204 and low TRPM1/miR-211 levels (Supplementary Figure 21). This evidence concerns the gene EDEM1 and metastatic melanoma.