NF-KBIL1 is a novel inhibitor of NF-κB signaling and the polymorphism rs2071592 in its gene promoter region has been reported to be significantly associated with rheumatoid arthritis (RA) [54] and systemic lupus erythematosus (SLE) [34]. This evidence concerns the gene NFKB1 and systemic lupus erythematosus.