Our results showed that 4 SNPs (CDKN2A rs3088440, NF-KBIL1 rs2071592, TRAF6 rs5030437 and IKBKB rs12676482) were related with the efficacy of radiotherapy and 3 SNPs (CDKN2A rs3088440, CCND1 rs9344 and IKBKB rs12676482) were related with the acute radiation-induced toxic reactions in NPC patients. Here, NFKBIL1 is linked to nasopharyngeal carcinoma.