CD44, a transmembrane glycoprotein that is involved in cell–cell and cell-matrix interactions either through its affinity for serglycin, hyaluronic acid (HA), or other ECM components, has been shown to be upregulated in various cancer types including glioma and increased expression of CD44 promotes the metastasizing and migratory potential of tumor cells [25]. Here, SRGN is linked to central nervous system cancer.