In the total splenic CD11c+ DC population, P.y-WT or P.y-GPC3 parasite-infected HCC-bearing mice activated a higher percentage of CD8α+ DCs than their control mice counterparts (56.67% or 64.43%, vs 40.51%), and the difference was statistically significant (P = 0.027 and P = 0.002). The gene discussed is CD8A; the disease is hepatocellular carcinoma.