STAT3 and hepatocellular carcinoma: The results showed that overexpression of STAT3 in cells transfected with pcDNA3.1-S dramatically increased the glucose consumption and lactate production in HepG2 and Hep3B cells, while the downregulation of STAT3 by siRNA dramatically reduced the glucose consumption and lactate production, indicating that STAT3 enhances glycolysis in HCC cells.