Naturally occurring oncolytic viruses, such as human Respiratory Syncytial virus, Newcastle disease virus, and Malabar virus, have therapeutic potential because massive replication of these pathogens can ultimately kill tumor cells [1–3]Considering that gene products in the IFN-α-stimulated pathway are frequently defective in cancer, ISGs may be useful as biomarkers for individualized treatments. The gene discussed is IFNA2; the disease is neoplasm.