The quantifications of SOCS3 and SOCS1 immunoreactivities in the epidermis of SCC and BCC skin tumors were evaluated by using a four-stage scoring system, and as shown in Figure 4A, a weak cytoplasmic expression of SOCS3 was observed in the epidermis of both NLS BCC and SCC skin, as well as of healthy skin (all specimens were scored 1+). Here, SOCS3 is linked to skin neoplasm.