CTRL and neoplasm: We observed that in absence of IL-22, mice treated with KIR-ESS peptide displayed reduced tumor volumes compared with those treated with Ctrl1 peptide or vehicle alone, reaching a final volume of 2.7 ± 0.15 cm3 for vehicle or 2.4 ± 0.18 cm3 for Ctrl1 groups and 1.5 ± 0.14 cm3 for KIR-ESS group (p < 0.05; Figure 7A).