Interestingly, in a recent meta-analysis of 27 clinical trials using PD-1/PD-L1 blocking agents, Gandini et al. showed that clinical trials using a 5% positivity cut-off for PD-L1 expression in tumor cells correlated with objective response, but the relationship was lost when a 1% positivity cut-off was used [21]. The gene discussed is CD274; the disease is neoplasm.