A similar synergistic effect was observed in thyroid cancer cell lines using RAF inhibitors (RAF265 and ZSTK474) with a Pi3′-kinase inhibitor (SB590885) in two PTC cell lines and in 8505c [30] or using a MEK inhibitor (AZD6244) with GDC-0941 on OCUT-1 cells and other PTC cell lines [31]. This evidence concerns the gene MAP2K7 and thyroid gland carcinoma.