Interestingly, it was also previously shown that blocking Pi3′-kinase can help overcome the resistance of some thyroid cancer cell lines to Tumor Necrosis Factor-Alpha-Related Apoptosis-Inducing Ligand (TRAIL) signaling (Lexatumumab), confirming the crucial role of Pi3′-kinase involvement in thyroid cancer cells’ drugs response [32]. This evidence concerns the gene TNFSF10 and thyroid cancer.