We further show that this effect is due to the reduction of collagen and hyaluronan tumor components as a result of TGFβ signaling pathway inhibition and downregulation of collagen I (COL1A1), collagen 3 (COL3), hyaluronan synthase 2 (HAS2), hyaluronan synthase 3 (HAS3) and transforming growth factor-beta 1 (TGFβ1) gene expression. Here, HAS2 is linked to neoplasm.