Nonetheless, inhibition of constitutive HIF-1α expression in renal cell carcinoma cell lines, mouse embryonic fibroblasts (MEF), 293 cells [39, 40], and significant reduction of constitutive VEGF-A production in a retinal pigmental epithelial cell line has been described [41]. The gene discussed is HIF1A; the disease is hereditary clear cell renal cell carcinoma.