In our study, we found that p-BCR-ABL and classical Wnt/β-catenin signaling were significantly down-regulated (i.e., Dvl-2 and β-catenin were significantly down-regulated and p-GSK3β was significantly up-regulated) when CFTR protein was reduced by CFTRinh-172 and shRNA in Ph+ acute leukemia cells. The gene discussed is GSK3B; the disease is acute leukemia.