We also found that CFTR still functioned as an ion channel in these cells based on the cytosolic pH values detected (it has been reported that CFTR regulates cytosolic pH values via mediating HCO3−transport): in leukemia cells, cytosolic pH values were reduced when exposed to CFTRinh-172 at low concentrations (20–50 μM), but there was no noticeable impact on HBE cells and normal human MNCs. This evidence concerns the gene CFTR and leukemia.