To elucidate the role of CFTR in leukemia cells, we analyzed the expression of CFTR protein in normal and leukemia cells and found that the mean level of CFTR expression in Ph+ acute leukemia cells (Ph+ B-ALL and CML-blast crisis) was markedly higher than in Ph-B-ALL and CML-chronic phase cells, with HBE cells as a positive control and normal mononuclear cells (MNCs) as a normal control. Here, CFTR is linked to leukemia.