In recent years, an enormous amount of research has shown that aberrant expression or mutation of CFTR is involved in the incidence and development of gastric cancer, colon cancer, lung cancer, breast cancer, prostate cancer, cervical cancer, ovarian cancer and other tumors [12–16].CFTR alterations differ among tumor types: in some cases, CFTR acts as a tumor suppressor gene (e.g., colon cancer and prostate cancer), whereas in others, it acts as an oncogene (e.g.,cervical cancer and ovarian cancer). Here, CFTR is linked to colonic neoplasm.