Other broadly dysregulated pathways in patients with HIVE (group D) as compared to patients with HIV without NCI (group B) indicate greater and broader activation of inflammatory and immune activation genes in group D as compared to group B. Genes regulated by both type I and type II IFN that were found activated in HIV infection without NCI (group B) as compared to uninfected controls, generally showed greater activation in patients with HIVE (group D). This evidence concerns the gene SGCG and HIV infectious disease.