CD274 and melanoma: One clinical study showed that treatment with anti-PD-L1 antibody leads to the inhibition of metastatic lesion growth in 21% and 26% patients with non-small cell lung cancer and melanoma, respectively [21], while other studies have indicated that treatment with anti-PD-1 or anti-PD-L1 antibodies at a dose of 1.0 mg/kg results in objective responses (41% and 29%, respectively) in melanoma patients [22,23].