Thereby, endothelial staining with the biotinylated STL and Cy2-streptavidin resulted in persisting, but partially thinned endothelia in ischemic neocortical areas (Fig 1A) as well as in the striatum (Fig 1B) as the primarily stroke-affected region due to the employed filament-based model of transient MCA occlusion. The gene discussed is RNF217-AS1; the disease is Stroke.