TGF-β signaling promotes tumor cell proliferation, survival, motility, invasion, metastatic colonization and acquisition of mesenchymal markers, such as increased Fibronectin and Vimentin expression, increased invasiveness, and exhibiting CD44+/CD24− phenotype toward BCSC progression straits through induction of EMT [150,151,152]. This evidence concerns the gene TGFB1 and neoplasm.