Several pathophysiological mechanisms of interaction between obesity and CRC have been studied, including insulin resistance, adipocytokine imbalances, alterations in the insulin-like growth factor (IGF)-1/IGF-1 receptor (IGF-1R) axis, chronic inflammation, and oxidative stress [8,9,10,11,12]. This evidence concerns the gene IGF1R and obesity due to melanocortin 4 receptor deficiency.